Informed Simplifications, LLC explores how the brain thinks and remembers. We are an independent research and development company dedicated to improving human health by providing tools, technology and knowledge that will enable physicians and scientists to solve and cure diseases of the brain. Our core technologies are informed simplifications based on our decades of laboratory neuroscience experience. Informed simplifications are biological insights that allow us to match the required complexity of brain simulations to neuromedical research problems and perform massive computations on everyday computers. Our goal is to put realistic and clinically relevant brain simulation tools on the desktop of every physician or scientist who wants to understand and improve cognition.